Lipopolysaccharide prolongs action potential duration in HL-1 mouse cardiomyocytes
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چکیده
منابع مشابه
Lipopolysaccharide prolongs action potential duration in HL-1 mouse cardiomyocytes.
Sepsis has deleterious effects on cardiac function including reduced contractility. We have shown previously that lipopolysaccharides (LPS) directly affect HL-1 cardiac myocytes by inhibiting Ca(2+) regulation and by impairing pacemaker "funny" current, I(f). We now explore further cellular mechanisms whereby LPS inhibits excitability in HL-1 cells. LPS (1 μg/ml) derived from Salmonella enterit...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2012
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00173.2012